Ursolic acid, a naturally occurring body recomposition agent

For over a decade, many supplement brands have claimed that CLA (Conjugated Linoleic Acid) has the properties of what is defined as a “ body recomposition agent .” That is, it is a molecule that increases fat loss while simultaneously facilitating lean muscle gain. Unfortunately, the effects of CLA are so weak that it is considered ineffective and completely useless. It should also be noted that some isomers of CLA are trans fatty acids, something the industry is careful not to tell you.

Indeed, the effects of trans fats are very often singled out by scientific research. Today, this fatty acid is practically forgotten, both by scientific research and by athletes or people on controlled diets. However, natural recomposition agents do exist, even if they are extremely rare. Ursolic acid and maslinic acid, pentacyclic triterpenes (secondary metabolites) do indeed exhibit this property. These two elementary molecules have indeed been studied by experimental science and their conclusions are particularly interesting, both for bodybuilders and sedentary people.

Taking advantage of the properties of ursolic acid on the French market is now possible

YAM Nutrition's Naturabolic is a source of ursolic acid designed to stimulate this body recomposition effect, facilitating the gain of lean muscle, from a diet rich in protein and carbohydrates. Indeed, the effects of ursolic acid have been validated by scientific research from numerous studies and meta-analyses that we will detail below (Katashima CK. et al. 2017).

This unique triterpene stimulates different cellular pathways to stimulate lean muscle gain and reduce fat accumulation.

Yet, even if Naturabolic is actually the first French dietary supplement intended for strength practitioners based on a body recomposition agent, it was not the first of them. Patrick Arnold, an American biochemist who remained famous in the USA for a case that has little to do with dietary supplements, returned to more rational and harmless subjects several years later by developing two brands of food supplements mainly based on ursolic acid. American bodybuilders could then test the supplements E-Pharm (Ursobolic) and Prototype Nutrition (Ur Spray). As a savvy scientist, Patrick Arnold knew that he could really offer innovative food supplements to strength and bodybuilding practitioners. Some European and French bodybuilders may have benefited from it, but it is difficult to know for sure. Today, the scientific community recognizes the positive effects of ursolic acid, particularly on these different points:

1. Increased thermogenesis by activation of 5′ AMP-activated protein kinase

2. Stimulation of the release of somatropin (growth hormone) and IGF-1 (Katashima CK. et al. 2017)

3. Accordingly → mTOR activation and inhibition of ubiquitin E3 ligase = Regulation of protein synthesis

4. Regulation of fatty acid storage and glucose metabolism by PPAR- γ or PPARG and SIRT1 (Katashima CK. et al. 2017)

5. Improved insulin sensitivity (Ramírez-Rodríguez et al. 2017, Jung 2007)

6. Increased age-related biomarkers (SIRT1 and PGC-1α) in isolated satellite cells → Proliferation of satellite cells (Bakhtiari et al. 2015)

7. Stimulation of neomyogenesis by increasing the number of satellite cells → Increase in lean muscle mass and muscle quality (Ibid.)

8. Complementary effect of Nicotinamide Riboside on certain aspects of metabolism regulation (Stimulation of SIRT1 and PGC-alpha)

9. Probable improvement in longevity with many cellular processes observed (SIRT1, SIRT6, PGC-1beta and alpha, and Klotho) (Seo DY et al. 2018)

10. Stimulation of the Akt/mTOR pathway , activation of muscle protein synthesis (Kunkel et al. 2011)

Naturabolic is a combination of ursolic acid extracted from rosemary and hesperidin extracted from citrus fruits.

With a source of ursolic acid, Naturabolic also provides you with hesperidin, a flavonoid extracted from citrus fruits and with anabolic potential via the MyoD pathway. This cellular process stimulates the differentiation of satellite cells into muscle cells (Jeong 2011). With ursolic acid and hesperidin , Naturabolic aims to stimulate lean muscle growth while activating fat loss through the mechanisms described above. Ursolic acid and hesperidin have been combined in a complementary manner to create the best possible synergy of effects. Piperine extracted from black pepper and vitamin B6 have been added to facilitate the assimilation of the formula's components. If you are looking for a dietary supplement that stimulates lean muscle synthesis, Naturabolic is the best natural solution on the market. Combined with Virilis V2 To boost testosterone and strength, you could treat yourself to two exceptional and completely natural muscle-building supplements.

Bibliography elements

• Bakhtiari et al., Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation . Med Hypotheses. 2015 Jul;85(1):1-6.
• Bakhtiari N, Hosseinkhani S, Soleimani M, Hemmati R, Noori-Zadeh A, Javan M, Tashakor A. Short-term ursolic acid promotes skeletal muscle rejuvenation through enhancement of SIRT1 expression and satellite cell proliferation . Biomed Pharmacother. 2016 Mar;78:185-196.
• Ebert SM, Al-Zougbi A, Bodine SC, Adams CM. Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies, Physiology. 2019 Jun 5; 34(4): 232-239
• Katashima CK. et al., Ursolic acid and mechanisms of actions on adipose and muscle tissue: a systematic review . Obes Rev. 2017 Jun;18(6):700-711.
• Kunkel SD, Suneja M, Ebert SM, Bongers KS, Fox DK, Malmberg SE, Alipour F, Shields RK, Adams CM, mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass . Cell Metab. 2011 Jun 8; 13(6):627-38.
• Jung SH, Ha YJ, Shim EK, Choi SY, Jin JL, Yun-Choi HS, Lee JR, Insulin-mimetic and insulin-sensitizing activities of a pentacyclic triterpenoid insulin receptor activator . Biochem J. 2007 Apr 15; 403(2):243-50.
• Ramírez-Rodríguez AM, González-Ortiz M, Martínez-Abundis E, Acuña Ortega N, Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation . J Med Food. 2017 Sep; 20(9):882-886.
• Seo DY, Lee SR, Heo JW, No MH, Rhee BD, Ko KS, Kwak HB, Han J. Korean, Ursolic acid in health and disease . J Physiol Pharmacol. 2018 May; 22(3):235-248.
• Woźniak Ł, Skąpska S, Marszałek K. Ursolic acid—a pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecules. 2015;20:20614–20641.